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The Middle East is Reshuffling the Deck. Is the U.S. Ready to Play a New Hand?

From the humanitarian crisis in Gaza to Iran’s strategic setbacks, Norm Roule details why the region’s turbulence demands fresh thinking from Washington

The Middle East is Reshuffling the Deck. Is the U.S. Ready to Play a New Hand?

NETZARIM CORRIDOR, GAZA - AUGUST 4: Palestinians flock to the Netzarim Corridor to receive limited food supplies as hunger deepens across Gaza amid ongoing Israeli attacks and blockade, on August 4, 2025.

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Photo by Hassan Jedi/Anadolu via Getty Images

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EXPERT INTERVIEW – The past year has brought a whirlwind of dramatic developments in the Middle East, reshaping long-held assumptions about the region’s balance of power and its future trajectory. From Israeli Prime Minister Benjamin Netanyahu now reportedly considering a complete military takeover of Gaza, where hunger and the humanitarian crisis are rampant, to a precedent-setting U.S.-Israel joint military strike on Iran, to an unprecedented Arab League demand that Hamas disarm, the strategic environment has shifted at a speed and scale not seen in years. Amid this upheaval, policymakers are reassessing red lines, rewriting rules of engagement, and navigating a fast-changing web of diplomatic, military, and economic relationships.

In this exclusive interview, Cipher Brief CEO & Publisher Suzanne Kelly speaks with former National Intelligence Manager for Iran at ODNI and Middle East expert Norman Roule, who offers a deep dive into the most consequential developments now unfolding across the region. Roule describes a reshuffled strategic “deck” that presents both peril and opportunity—from the collapse of key Iranian nuclear infrastructure, to a potential turning point in Syria’s post-Assad future, to new roles for Gulf states investing billions in regional stabilization.

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